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Bioactive Crude Plant Seed Extracts from the NCAUR Oilseed Repository (National Center for Agricultural Utilization Research, Illinois)

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Title: Bioactive Crude Plant Seed Extracts from the NCAUR Oilseed Repository (National Center for Agricultural Utilization Research, Illinois)
Author : Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
Release Date : January 01, 2003
Genre: Life Sciences,Books,Science & Nature,
Pages : * pages
Size : 255 KB

Description

Summary Over four-hundred crude extracts from 202 plant species distributed among 131 plant families were evaluated for their bioactivity against brine shrimp (Artemia salina). Activity was determined for both the organic [CH.sub.2] [CI.sub.2]:MeOH) and aqueous extracts against A. salina in a 96 well-plate assay. Of the greater than four-hundred extracts tested, 21 organic and 6 aqueous extracts demonstrated potent cytotoxic activity [LC.sub.50] = 100 [micro]g/ml). Three of these organic extracts (Crateva religiosa, Diospyros dichrophylla, and Olax subscorpioidea) were chosen for chemical investigations due to their high activity and a lack of prior investigations. Chemical analysis of these extracts resulted in the isolation of oleanolic acid (1) and 4-epi-hederagenin (2) from C. religiosa, isodiospyrin (3) from D. dichrophylla, and santalbic acid (4) from O. subscorpioidea.